Key result
Prolonged nocturnal recumbency in patients with neurogenic orthostatic hypotension led to lower standing blood pressure in the morning versus the evening (P<0.01) due to reduced stroke volume.
Why the study?
Does prolonged nocturnal recumbency alter haemodynamics upon standing in the morning compared to the evening in patients with neurogenic orthostatic hypotension?
Population
10 patients with neurogenic orthostatic hypotension, of which seven were being treated with fludrocortisone…
Comparison
Standing for 5 min in the morning after… vs Standing for 5 min in the evening (22.30 hours)
Design
Cohort
Follow-up
24 hours
Authors
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May worsen morning orthostatic tolerance in neurogenic orthostatic hypotension; hypothesis-generating for nocturnal fluid shifts on stroke volume.
Observational (n=10)
Does prolonged nocturnal recumbency alter haemodynamics upon standing in the morning compared to the evening in patients with neurogenic orthostatic hypotension?
p-value: p=<0.01
In patients with neurogenic orthostatic hypotension, impaired orthostatic tolerance in the morning is driven by larger falls in stroke volume and cardiac output, likely due to nocturnal polyuria and body fluid redistribution.
Omboni et al. (2001) conducted an observational in neurogenic orthostatic hypotension (n=10). Standing in the morning (after nocturnal recumbency) vs. Standing in the evening was evaluated on Standing blood pressure values (p=<0.01). Prolonged nocturnal recumbency in patients with neurogenic orthostatic hypotension led to lower standing blood pressure in the morning versus the evening (P<0.01) due to reduced stroke volume.
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