Key result
CD44-targeted Iron-Doxorubicin Hyaluronan Nanogel inhibits murine breast tumors and reduces toxicity vs free doxorubicin.
Why the study?
Does Iron-Doxorubicin Hyaluronan Nanogel improve tumor inhibition and reduce toxicity compared to free doxorubicin in murine breast tumors?
Does Iron-Doxorubicin Hyaluronan Nanogel improve tumor inhibition and reduce toxicity compared to free doxorubicin in murine breast tumors?
The HA@Dox nanogel provides targeted delivery, significant tumor inhibition, and reduced doxorubicin-induced toxicity in a preclinical murine model.
Should not alter doxorubicin regimens in breast cancer; leaves open translation of CD44-targeted nanogels to reduce cardiotoxicity.
) coordination to control the intracellular distribution and release of Dox. Taking advantage of the paramagnetic properties of iron and the fluorescence of Dox, we conveniently monitored the targeted delivery of the HA@Dox nanogel in murine breast tumors through both T1-weighted magnetic resonance imaging and fluorescence imaging. Compared with free Dox, HA@Dox nanogel affords a CD44-targeted delivery, lysosomal distribution, pH-responsive release, and significant tumor inhibition. Mechanistically, the lysosome-enriched HA@Dox produces ROS, causing lysosomal membrane permeabilization, which further promotes the intracellular Dox distribution. This HA@Dox nanogel not only provides a facile cancer-targeted delivery but also successfully relieves Dox toxicity, representing a potent delivery system for Dox.
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Guo et al. (2025) studied Murine breast tumors. Iron-Doxorubicin Hyaluronan Nanogel (HA@Dox) vs. Free Doxorubicin was evaluated on Tumor inhibition and targeted delivery. Iron-Doxorubicin Hyaluronan Nanogel provided CD44-targeted delivery, significant tumor inhibition, and relieved doxorubicin toxicity compared with free doxorubicin in murine breast tumors.
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