Key result
Peripartum cardiomyopathy is linked to lower irisin levels and higher FNDC5 A/A homotype prevalence.
Why the study?
Peripartum cardiomyopathy can develop late in pregnancy or soon after delivery, but the association of irisin expression and FNDC5 (rs3480) gene polymorphism with the condition required assessment.
Is there an association between irisin expression and FNDC5 (rs3480) gene polymorphism and peripartum cardiomyopathy?
Case-Control (n=90)
Is there an association between irisin expression and FNDC5 (rs3480) gene polymorphism and peripartum cardiomyopathy?
Irisin levels are significantly reduced in patients with peripartum cardiomyopathy and may be associated with the FNDC5 A/A genotype, suggesting a potential biomarker or pathophysiological role.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for irisin as a peripartum cardiomyopathy biomarker; prospective studies needed before clinical adoption.
Background: Late in pregnancy or soon after delivery, peripartum cardiomyopathy (PPCM) which is an uncommon type of cardiomyopathy, can develop. To assess the association between the level of irisin expression and (FNDC5) (rs3480) gene polymorphism with peripartum cardiomyopathy. Methods: This is a case control study included a thirty female patients with new-onset PPCM and sixty healthy females at the at the peripartum period in same time window for PPCM as a control. For each patient, comprehensive medical history was taken, full clinical assessment was done, ECHO., FNDC5 (rs3480) & Irisin assay. Results: The left ventricle end diastolic dimensions &left atrium diameters were statistically significant higher in patients' group than controls' group (P=0.000 for all), Also left ventricular ejection fraction (%) was statistically significant lower in patients than controls and as regards irisin, its Mean ±SD was lower in patient group than control group (8.44±1.1 vs 10.65±2.31) with (p <0.001) which is considered a significant difference statistically. Conclusion: Irisin level was lower in peripartum cardiomyopathic patients when compared with normal individuals and regarding its genotype, the homotype A/A was higher than homotype G/G.
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Altaher et al. (2024) conducted a case-control in peripartum cardiomyopathy (n=90). FNDC5 (rs3480) gene polymorphism and irisin level vs. Healthy females at the peripartum period was evaluated on Irisin level (p=<0.001). Irisin levels were lower in patients with peripartum cardiomyopathy compared to healthy controls, and the FNDC5 homotype A/A was more prevalent.
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