Key result
Female sex is linked to ~36% greater syncope risk in pediatric vasovagal patients.
Why the study?
This study was conducted to investigate the relationship between demographic factors and syncopal symptoms in pediatric vasovagal syncope using 20 years of clinical data.
Are demographic factors associated with the risk of syncope versus pre-syncope in pediatric patients with vasovagal syncope?
Observational (n=2,513)
No
Are demographic factors associated with the risk of syncope versus pre-syncope in pediatric patients with vasovagal syncope?
Effect estimate: OR 1.36 (95% CI 1.15-1.60)
p-value: p=0.000
Demographic factors such as age, sex, height, and weight are significantly associated with the presentation of syncope versus pre-syncope in pediatric vasovagal syncope.
Female sex and older age were associated with higher syncope risk in pediatric VVS; hypothesis-generating and should not yet change practice.
This research proposed to retrospectively analyze 20 years of clinical data and investigate the relationship between demographic factors and syncopal symptom in pediatric vasovagal syncope. A total of 2513 children, 1124 males and 1389 females, age range 3-18 years, who presented to Department of Pediatric Cardiovasology, Children's Medical Center, The Second Xiangya Hospital, Central South University with unexplained syncope or pre-syncope and were diagnosed with vasovagal syncope were retrospectively collected and divided into syncope group (n = 1262) and pre-syncope group (n = 1251). (1) Females had a 36% increased risk of syncope compared to males, a 27% increased risk of syncope for every 1-year increase in age, and a 2% decreased risk of syncope for every 1 cm increase in height. (2) A non-linear relationship between age, height, weight and syncope was observed. When age > 10.67 years, the risk of syncope increases by 45% for each 1-year increase in age; when height < 146 cm, the risk of syncope decreases by 4% for each 1 cm increase in height; when weight < 28.5 kg, the risk of syncope decreases by 10% for each 1 kg increase in weight. Demographic factors are strongly associated with syncopal symptom in pediatric vasovagal syncope and can help to predict the risk.
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Wang et al. (2023) conducted an observational in Pediatric vasovagal syncope (n=2,513). Female sex vs. Male sex was evaluated on Occurrence of syncope (OR 1.36, 95% CI 1.15-1.60, p=0.000). In pediatric vasovagal syncope, females had a 36% increased risk of syncope compared to males, and the risk increased by 27% for each 1-year increase in age.
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