Key result
Short-term exercise fails to improve endothelial function in prediabetes despite improved glucose and insulin responses.
Why the study?
The impact of interval versus continuous exercise training on endothelial function in relation to glucose metabolism prior to clinically meaningful weight loss is unknown in adults with prediabetes.
Does short-term interval vs. continuous exercise training improve endothelial function and glucose metabolism in obese adults with prediabetes?
Does short-term interval vs. continuous exercise training improve endothelial function and glucose metabolism in obese adults with prediabetes?
p-value: p=0.83
Short-term exercise training improves glucose metabolism but does not consistently improve endothelial function in obese adults with prediabetes.
Short-term exercise does not reliably improve endothelial function in prediabetes; leaves open longer-term or combined interventions for vascular benefits.
INTRODUCTION: The impact of interval (INT) vs. continuous (CONT) exercise training on endothelial function in relation to glucose metabolism prior to clinically meaningful weight loss is unknown in adults with prediabetes. METHODS: ) and body composition (bioelectrical impedance) were assessed before and after training. Flow-mediated dilation (FMD) was measured during a 2 h 75 g OGTT (0, 60, and 120 min) to assess endothelial function. Postprandial FMD was calculated as incremental area under the curve (iAUC). Glucose tolerance and insulin were also calculated by iAUC. Fasting plasma VCAM, ICAM, and hs-CRP were also assessed as indicators of vascular/systemic inflammation. RESULTS: = 0.83, respectively). CONCLUSION: Endothelial function is not improved consistently after short-term training, despite improvements in glucose and insulin responses to the OGTT in obese adults with prediabetes.
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Malin et al. (2019) studied Prediabetes. Interval (INT) exercise training vs. Continuous (CONT) exercise training was evaluated on Endothelial function (Flow-mediated dilation during OGTT) (p=0.83). Short-term interval and continuous exercise training did not consistently improve endothelial function (P=0.83), despite improvements in glucose and insulin responses in obese adults with prediabetes.
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