Key result
A 24-week exercise program improves vascular endothelial function in middle-aged patients with impaired glucose tolerance.
Why the study?
Does a 24-week exercise intervention improve vascular endothelium functions and glucose metabolism in middle-aged patients with impaired glucose tolerance?
RCT (n=61)
Randomly divided into three groups
No
Does a 24-week exercise intervention improve vascular endothelium functions and glucose metabolism in middle-aged patients with impaired glucose tolerance?
A 24-week exercise intervention significantly improves endothelium-dependent vasodilation and insulin sensitivity in middle-aged patients with impaired glucose tolerance, potentially preventing early diabetes mellitus.
Answers are grounded in this paper and cite their sources.
Exercise may improve endothelial markers in IGT; hypothesis-generating and requires confirmation in RCTs before practice change.
Endothelial dysfunction (ED) is an early pathophysiological change in patients with impaired glucose tolerance (IGT) during prediabetes mellitus. This study was designed to test the hypothesis that exercise intervention contributes to the reversal of vascular endothelium-dependent dysfunction in middle-aged patients with IGT. Following exercise intervention, significant changes in endothelin (ET)-1, C-type natriuretic peptide (CNP), ΔDia-P, oral glucose tolerance test (OGTT)2h, fasting insulin, homeostasis model of assessment-insulin resistance (HOMA-IR), body fat percentage, waist circumference and waist to hip ratio were measured. However, no marked changes in carotid artery intima-media thickness (IMT), fasting blood glucose and BMI were observed following exercise intervention. Validity analysis of index changes in the two exercise intervention groups further confirmed there was no change. Exercise intervention increased CNP levels, decreased ET-1 levels and increased ΔDia-P, indicating improved vascular endothelium function. Decreased HOMA-IR following exercise suggests enhanced insulin sensitivity. Exercise intervention also improved glucose metabolism via decreased OGTT2h and fasting insulin. In addition, decreased waist circumference, ratio of waist to hip and body fat percentage following exercise intervention improved changes of body composition, including BMI, body fat and waist circumference. These results indicate that exercise intervention may reverse vascular endothelium-dependent dysfunction in middle-aged patients with IGT. This study also provided direct clinical data supporting the use of exercise intervention to prevent diabetes mellitus (DM) during the early stage.
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Liu et al. (2013) conducted an RCT in Impaired glucose tolerance during prediabetes mellitus (n=61). Exercise intervention (walking or walking plus resistance exercise) vs. No exercise was evaluated on C-type natriuretic peptide (CNP) levels (pg/ml) (p=<0.001). A 24-week exercise intervention significantly improved vascular endothelium functions, including increased C-type natriuretic peptide and decreased endothelin-1 levels, in middle-aged patients with impaired glucose tolerance.
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