Preeclampsia history was the strongest determinant of hypertension (P<0.0001), and central adiposity further worsened 24-h systolic blood pressure by 15.6 mmHg and pulse wave velocity by 1.14 m/s.
Case-Control (n=1,775)
Does central adiposity worsen blood pressure and arterial stiffness in young women with a history of preeclampsia?
In young women with a history of preeclampsia, central adiposity significantly exacerbates vascular impairment and increases blood pressure.
Effect estimate: 19-fold higher risk
p-value: p=<0.0001
OBJECTIVE: Cardiovascular disease (CVD) remains the leading cause of mortality and is often underestimated in women, particularly in those with a history of preeclampsia (PE). Obesity has increased every year, with countries being unsuccessful in reducing its prevalence. This study aimed to evaluate cardiovascular outcomes in women aged less than 40 years old, considering both PE history and central adiposity (CA). METHODS: We conducted a retrospective case-control study using data from a Brazilian cohort initiated in 1978/1979, with follow-up in 2016/2017. Of the 1775 individuals evaluated, 929 were women, and 188 reported their PE history. Women were categorized as having PE history or no PE history (CTL) and further classified by the presence of CA (waist circumference ≥88 cm). Cardiovascular events, blood pressure, and arterial stiffness were also recorded. RESULTS: Hypertension was present in 66. 7 and 69. 7% of women with PECA and PEₙoCA, respectively. The risk was 19-fold higher in PECA and 24-fold higher in PEₙoCA than in CTLₙoCA. Conditional inference tree (CTree) analysis confirmed that PE preeclampsia (P < 0. 0001) was the strongest determinant of hypertension, followed by CA (P < 0. 0001) and dyslipidemia (P = 0. 019). CA significantly worsened SBP 24-h ambulatory blood pressure monitoring (ABPM) +15. 6 mmHg; daytime ABPM +15. 9 mmHg; office + 15. 3 mmHg and increased pulse wave velocity (PWV) by 1. 14 m/s among women with history of PE. CONCLUSION: PE significantly increased the cardiovascular risk, with CA further exacerbating vascular impairment. Early cardiovascular risk assessment and prevention strategies are essential for young women with a history of PE to prevent future cardiovascular events.
Barbosa et al. (Tue,) conducted a case-control in Preeclampsia history and central adiposity (n=1,775). Preeclampsia history and central adiposity vs. No preeclampsia history without central adiposity was evaluated on Hypertension (19-fold higher risk, p=<0.0001). Preeclampsia history was the strongest determinant of hypertension (P<0.0001), and central adiposity further worsened 24-h systolic blood pressure by 15.6 mmHg and pulse wave velocity by 1.14 m/s.