Oxygenation and vascularization of pancreatic islet graft: An overview

Treatment of type 1 diabetes is based on exogenous insulin injections and has drastically improved diabetes mortality and morbidity. Nevertheless, this therapy failed to control effectively and safely the glycaemic levels in some patients suffering from brittle diabetes. For these patients, morbidity and mortality remain high despite improved metabolic results, but transplantation development of pancreatic islets allowed to achieve optimal glycaemic control and insulin-independency (with an acceptable safety profile in comparison to pancreas organ transplantation).