Why the study?
Does clopidogrel response variability correlate with P2Y12 receptor occupancy in healthy subjects?
Population
36 healthy subjects selected based on initial response to clopidogrel 75 mg/day
Comparison
Clopidogrel 75 mg/day for 10 days, followed by… vs Placebo (n=2/group)
Design
RCT, randomized, double-blind
Follow-up
11 days
Authors
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May inform dose escalation strategies in clopidogrel low responders; confirms P2Y12 occupancy as mechanistic driver of response variability.
Does clopidogrel response variability correlate with P2Y12 receptor occupancy in healthy subjects?
Variability in clopidogrel response is linked to differences in P2Y12 receptor occupancy, and an additional 300 mg loading dose can improve response in low responders.
Sollier et al. (2008) studied this question.
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