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April 7, 2023Journal of the American Heart AssociationOpen Access

Health‐Related Quality of Life and Its Association With Outcomes in Adults With Congenital Heart Disease and Heart Failure: Insight From FRESH‐ACHD Registry

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Key result

Poor QoL in ACHD with HF links to severe events but is not independently predictive.

Why the study?

Is health-related quality of life associated with cardiovascular events in adults with congenital heart disease and heart failure?

Population

Adults with congenital heart disease and heart failure

Comparison

Poor vs better health-related quality of life

Design

Registry-based study

Authors

RLReaksmei LyClinique PasteurCKClément KarsentyPediatric / Congenital CardiologyPAPascal AmédroUniversité de Bordeaux

Discussion

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Implication

Should not yet inform risk stratification in ACHD-HF; hypothesis-generating for interventional trials.

Key Points

  • The study examines how health-related quality of life is linked to health outcomes in adults with congenital heart disease and heart failure.
  • Analysis of data from the FRESH‐ACHD Registry
  • Assessment of quality of life using SF-36 dimensions
  • Multivariable analysis to determine predictors of cardiovascular events
  • Quality of life measurements predict higher rates of cardiovascular events (P=0.002).
  • After multivariable analysis, SF-36 dimensions were not significantly associated with the primary endpoint.
  • Patients with congenital heart disease and heart failure report worse quality of life and face more severe events.

Study Design

Type

Observational

Structured PICO

Is health-related quality of life associated with cardiovascular events in adults with congenital heart disease and heart failure?

P
Population
Adults with congenital heart disease and heart failure (FRESH-ACHD Registry)
O
Outcome
Cardiovascular eventshard clinical

While poor quality of life is associated with severe events in adults with congenital heart disease and heart failure, SF-36 dimensions are not independent predictors after multivariable adjustment.

Cite This Study

Ly et al. (2023) conducted an observational in Congenital Heart Disease and Heart Failure. Health-Related Quality of Life (SF-36) was evaluated on Cardiovascular events. Poor quality of life in adults with congenital heart disease and heart failure is associated with more frequent severe events, though not independently predictive after multivariable adjustment.

synapsesocial.com/papers/6a0872f9280cd4e998e8bfc9https://doi.org/10.1161/jaha.122.027819

Topics

Congenital heart disease adultsHeart failureHFrEF treatment
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