Why the study?
Does zofenopril calcium alter the time course of ACE inhibition and renin-angiotensin-aldosterone blockade in patients with acute myocardial infarction?
Population
20 patients with acute myocardial infarction, studied in hospital within 24 hours from symptoms.
Comparison
Zofenopril calcium in increasing doses vs Placebo
Design
RCT, randomized, placebo-controlled
Follow-up
at least 3 days (11 sampling periods in hospital)
Authors
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Aldosterone escape may occur by day 3 despite sustained ACE inhibition post-MI; extends RAAS time-course data in acute settings.
Does zofenopril calcium alter the time course of ACE inhibition and renin-angiotensin-aldosterone blockade in patients with acute myocardial infarction?
Zofenopril treatment in acute myocardial infarction demonstrates a dissociation between persistent ACE inhibition and a partial escape of aldosterone suppression after 3 days.
Borghi et al. (1993) studied this question.
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