Key result
CACNA1C and KCNH2 risk variants linked to increased HR and QT variability in unmedicated schizophrenia.
Why the study?
To test for associations between genetic findings in CACNA1C and KCNH2 and CADF parameters in schizophrenia patients uninfluenced by psychopharmaceuticals.
Do CACNA1C and KCNH2 risk variants alter heart rate dynamics and QT variability in unmedicated schizophrenia patients?
Case-Control (n=221)
Do CACNA1C and KCNH2 risk variants alter heart rate dynamics and QT variability in unmedicated schizophrenia patients?
Genetic risk variants in CACNA1C and KCNH2 are associated with altered cardiac autonomic function (increased HR and QT variability) in unmedicated schizophrenia patients, potentially predisposing them to arrhythmias.
May signal arrhythmia vulnerability warranting ECG vigilance in schizophrenia; extends CACNA1C/KCNH2 links to autonomic measures but remains hypothesis-generating.
BACKGROUND: are promising candidates. In this study, we tested for associations between genetic findings in both genes and CADF parameters in schizophrenia patients whose heart functions were not influenced by psychopharmaceuticals. METHODS: SNPs were found and genotyped in 77 unmedicated schizophrenia patients and 144 healthy controls. Genotype-related impacts on heart rate (HR) dynamics and QT variability indices (QTvi) were analyzed separately in patients and healthy controls. RESULTS: rs11763131 A, rs3807373 A, rs3800779 C, rs748693 G, and 1036145 T showed increased mean HR and QTvi as compared to non-risk alleles. CONCLUSIONS: associated with CADF in schizophrenia patients, independent of antipsychotic medication, that predisposes them to cardiac arrhythmias and premature death.
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Refisch et al. (2022) conducted a case-control in Schizophrenia (n=221). CACNA1C and KCNH2 risk variants vs. Non-risk alleles was evaluated on Heart rate (HR) dynamics and QT variability indices (QTvi). CACNA1C and KCNH2 risk variants showed increased mean heart rate and QT variability indices compared to non-risk alleles in unmedicated schizophrenia patients.
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