Key result
CHRM2 risk variants are linked to altered HRV in unmedicated patients with schizophrenia.
Why the study?
To test for possible associations between muscarinic acetylcholine receptor M2 polymorphisms and heart rate variability in patients with schizophrenia.
Do genetic risk variants of the muscarinic acetylcholine receptor M2 associate with altered heart rate variability in patients with schizophrenia?
Observational (n=293)
Do genetic risk variants of the muscarinic acetylcholine receptor M2 associate with altered heart rate variability in patients with schizophrenia?
Common genetic risk variants of the muscarinic acetylcholine receptor M2 are associated with cardiac autonomic dysfunction in unmedicated patients with schizophrenia.
CHRM2 variants may link to autonomic dysfunction in schizophrenia; hypothesis-generating and requires prospective validation before clinical relevance.
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Refisch et al. (2022) conducted an observational in Schizophrenia (n=293). CHRM2 genetic risk variants (rs73158705, rs8191992, rs2350782) vs. Genotype non-risk status was evaluated on Parameters of heart rate variability and complexity. CHRM2 genetic risk variants were significantly associated with altered heart rate variability in unmedicated patients with schizophrenia compared to non-risk genotypes.
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