Key result
Antipsychotics with high muscarinic affinity significantly reduced low-frequency power (β = -0.447; P < 0.001), high-frequency power, and total power compared to low muscarinic affinity drugs.
Why the study?
Do antipsychotics with high muscarinic affinity reduce parasympathetic modulation (measured by HRV) compared to those with low muscarinic affinity in patients with schizophrenia?
Population
55 patients with schizophrenia
Comparison
Antipsychotics with high muscarinic affinity (HMA) vs Antipsychotics with low muscarinic affinity (LMA)
Design
Cross-sectional
Authors
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High muscarinic affinity antipsychotics were associated with reduced HRV in schizophrenia; hypothesis-generating and requires prospective validation before clinical consideration.
Cross-Sectional (n=55)
Do antipsychotics with high muscarinic affinity reduce parasympathetic modulation (measured by HRV) compared to those with low muscarinic affinity in patients with schizophrenia?
Effect estimate: β = -0.447 for LF
p-value: p=<0.001 for LF
Antipsychotics with high muscarinic affinity significantly reduce both sympathetic and parasympathetic modulation compared to those with low affinity, and their effects on HRV are further influenced by concomitant anticholinergic use.
Huang et al. (2013) conducted a cross-sectional in Schizophrenia (n=55). Antipsychotics with high muscarinic affinity (HMA) vs. Antipsychotics with low muscarinic affinity (LMA) was evaluated on Heart rate variability (LF, HF, TP, and LF%) (β = -0.447 for LF, p=<0.001 for LF). Antipsychotics with high muscarinic affinity significantly reduced low-frequency power (β = -0.447; P < 0.001), high-frequency power, and total power compared to low muscarinic affinity drugs.
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