November 14, 2012BMC PsychiatryOpen Access

Dose-dependent effect of antipsychotic drugs on autonomic nervous system activity in schizophrenia

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Why the study?

Do antipsychotic drugs dose-dependently decrease autonomic nervous system activity in patients with schizophrenia?

Population

211 Japanese patients with schizophrenia on standard psychotropic medication, and 44 healthy controls.

Comparison

Antipsychotic drugs categorized by daily dose. vs Healthy controls not taking medication, and…

Design

Cross-sectional

Authors

YIYohko IwamotoYokohama City University CKChiaki KawanishiSapporo Medical University IKIkuko KishidaKarolinska University Hospital

Discussion

Member takes

Implication

Antipsychotic dose was associated with lower HRV; leaves open whether dose minimization improves autonomic function in schizophrenia.

Structured PICO

Do antipsychotic drugs dose-dependently decrease autonomic nervous system activity in patients with schizophrenia?

Population

211 Japanese patients with schizophrenia (166 inpatients, 45 outpatients; mean age 53.8, 129 women/82 men) on standard psychotropic medication, and 44 healthy controls (mean age 48.4, 30 women/14 men).

Intervention

Antipsychotic drugs categorized by daily dose (low ≤500 mg/day, medium 501-1000 mg/day, high ≥1001 mg/day chlorpromazine equivalent).

Comparator

Healthy controls not taking medication, and comparison across the three antipsychotic dose subgroups.

Outcome

Autonomic nervous system activity assessed by heart rate variability (HRV) power spectral analysis (low-frequency and high-frequency components) measured over 5 minutes at rest.surrogate

Antipsychotic drugs exert a significant dose-dependent decrease on autonomic nervous system activity in patients with schizophrenia, highlighting the need for optimal dosing to avoid cardiovascular adverse events.

Limitations

Relatively small sample size despite >200 patients.
Did not analyze the influence of each drug separately because most subjects were treated with multiple drugs.
No medication-free patients, making it unclear whether pathomechanisms and/or severity of schizophrenia directly affect ANS activity.

Cite This Study

Iwamoto et al. (2012) studied this question.

synapsesocial.com/papers/6a708dd9b5c1fe5ca9dfba6d https://doi.org/10.1186/1471-244x-12-199

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Dose-dependent effect of antipsychotic drugs on autonomic nervous system activity in schizophrenia

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Dose-dependent effect of antipsychotic drugs on autonomic nervous system activity in schizophrenia

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider