Key result
Hypoxaemic COPD was associated with significant autonomic dysfunction, present in 82% of patients (35% definite, 47% early) compared to 18% of age-matched controls.
Why the study?
Does hypoxaemic COPD cause cardiovascular autonomic dysfunction compared to age-matched controls?
Case-Control (n=118)
Does hypoxaemic COPD cause cardiovascular autonomic dysfunction compared to age-matched controls?
Absolute Event Rate: 82% vs 18%
Subclinical cardiovascular autonomic neuropathy is highly prevalent in patients with hypoxaemic COPD and correlates with the severity of hypoxaemia, but is not reversed by acute oxygen or bronchodilator therapy.
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May warrant autonomic assessment in hypoxaemic COPD; leaves open prognostic impact and reversibility with therapy.
Stewart et al. (1991) conducted a case-control in Hypoxaemic chronic obstructive pulmonary disease (n=118). Hypoxaemic COPD vs. Age-matched controls was evaluated on Autonomic dysfunction (early or definite). Hypoxaemic COPD was associated with significant autonomic dysfunction, present in 82% of patients (35% definite, 47% early) compared to 18% of age-matched controls.
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