Why the study?
Does metabolic scar assessment with 18F-FDG PET correlate with ischemic ventricular tachycardia substrate and successful ablation sites?
Does metabolic scar assessment with 18F-FDG PET correlate with ischemic ventricular tachycardia substrate and successful ablation sites?
18F-FDG PET imaging can identify metabolic scar characteristics that correlate highly with ischemic VT substrate, offering potential targets for imaging-guided ablation.
FDG PET may aid ischemic VT substrate localization; leaves open whether imaging-guided ablation improves outcomes.
F-FDG uptake categories could be detected using incremental 3D step-up reconstructions. They predicted decreasing bipolar voltages and VT channel or exit sites in about 90% of cases. Additionally, functional imaging allowed detection of novel molecular tissue characteristics within the ischemic VT substrate such as metabolic channels, rapid-transition areas, and metabolism-voltage mismatches demonstrating intrasubstrate heterogeneity and providing possible targets for imaging-guided ablation.
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Ghzally et al. (2021) studied this question.
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