What does this research mean for the field?

The concurrent presence of Mll-PTD and Flt3-ITD mutations induces acute myeloid leukemia with 100% penetrance in mice, demonstrating that Mll-PTD acts as a gain-of-function mutation in leukemogenesis. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to reveal the role of MLL-PTD and FLT3-ITD mutations in the development of acute myeloid leukemia.

June 7, 2012BloodOpen Access

Mll partial tandem duplication and Flt3 internal tandem duplication in a double knock-in mouse recapitulates features of counterpart human acute myeloid leukemias

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Authors

NZNicholas A. ZorkoUniversity of Minnesota KBKelsie M. BernotFlorida Atlantic University SWSusan P. WhitmanThe Ohio State University Wexner Medical Center

Discussion

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Implication

Randomized trial demonstrates acute leukemia development in mice with MLL-PTD and FLT3-ITD, suggesting insight into human AML mechanisms.

Key Points

This research aims to reveal the role of MLL-PTD and FLT3-ITD mutations in the development of acute myeloid leukemia.
Generated Mll(PTD/WT):Flt3(ITD/WT) double knock-in mice.
Evaluated the development of acute leukemia and associated genetic characteristics at 49 weeks.
Assessed the latency of AML in homozygous Flt3-ITD mice (Mll(PTD/WT):Flt3(ITD/ITD)).
Mll(PTD/WT):Flt3(ITD/WT) mice developed acute leukemia with 100% penetrance.
Mice with homozygous Flt3-ITD displayed a nearly 30-week reduction in latency to overt AML compared to heterozygous mice.

Cite This Study

Zorko et al. (2012) studied this question.

synapsesocial.com/papers/6a087c33df3db87398109a49 https://doi.org/10.1182/blood-2012-03-415067

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Mll partial tandem duplication and Flt3 internal tandem duplication in a double knock-in mouse recapitulates features of counterpart human acute myeloid leukemias

Discussion

Member takes

Implication

Key Points

Cite This Study

Mll partial tandem duplication and Flt3 internal tandem duplication in a double knock-in mouse recapitulates features of counterpart human acute myeloid leukemias

Discussion

Member takes

Implication

Key Points

Cite This Study

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