What question did this study set out to answer?

To evaluate the impact of interleukin-1 (IL-1) blockade using anakinra in patients with obese heart failure with preserved ejection fraction.

August 1, 2018Circulation Heart FailureOpen Access

IL-1 Blockade in Patients With Heart Failure With Preserved Ejection Fraction

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Key result

IL-1 blockade with anakinra shows favorable hs-CRP and NT-proBNP trends in obese HFpEF.

Authors

BTBenjamín W. Van TassellHeart Failure & Transplant CTCory R. TrankleHeart Failure & Transplant JCJustin M. CanadaHeart Failure & Transplant

Discussion

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Implication

Supports IL-1 blockade testing in obese HFpEF; extends anti-inflammatory strategies in preserved ejection fraction.

Key Points

To evaluate the impact of interleukin-1 (IL-1) blockade using anakinra in patients with obese heart failure with preserved ejection fraction.
Clinical trial evaluating anakinra therapy in obese patients with heart failure with preserved ejection fraction (HFpEF) (ClinicalTrials.gov: NCT02173548).
Monitored changes in inflammatory and cardiac stress biomarkers, including high-sensitivity C-reactive protein (hs-CRP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP).
Anakinra treatment resulted in favorable reductions in high-sensitivity CRP and NT-proBNP levels in obese HFpEF patients.
Observed biomarker trends support further clinical investigation of IL-1 blockade in this specific heart failure population.

Cite This Study

Tassell et al. (2018) studied this question. IL-1 blockade with anakinra demonstrated favorable trends in high-sensitivity CRP and NT-proBNP levels among obese patients with heart failure with preserved ejection fraction.

synapsesocial.com/papers/6a087f67ab15ea61dee8e2ce https://doi.org/10.1161/circheartfailure.118.005036

Topics

HFrEF treatment Heart failure

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IL-1 Blockade in Patients With Heart Failure With Preserved Ejection Fraction

Discussion

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Implication

Key Points

Cite This Study

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IL-1 Blockade in Patients With Heart Failure With Preserved Ejection Fraction

Discussion

Member takes

Implication

Key Points

Cite This Study

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