Why the study?
Does a low NT-proBNP level (≤125 pg/mL) reliably exclude the diagnosis of HFpEF in overweight and obese patients?
Population
30 stable patients with heart failure with preserved ejection fraction, median age 54, 66% women, 53%…
Comparison
NT-proBNP > 125 pg/mL vs NT-proBNP ≤ 125 pg/mL
Design
Cross-sectional
Authors
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Low NT-proBNP should not exclude HFpEF in obese patients; leaves open optimal cut-offs and requires prospective validation.
Does a low NT-proBNP level (≤125 pg/mL) reliably exclude the diagnosis of HFpEF in overweight and obese patients?
In overweight and obese patients, a low NT-proBNP level (≤125 pg/mL) does not reliably exclude the diagnosis of HFpEF, as these patients exhibit similar degrees of diastolic dysfunction and impaired exercise capacity as those with elevated levels.
Buckley et al. (2018) studied this question.
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