Why the study?
What is the prevalence of prolonged QTc and its clinical associations in children and young adults with sickle cell disease?
Population
76 children and young adults with sickle cell disease at steady state enrolled in a pulmonary hypertension…
Design
Cross-sectional
Authors
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QTc prolongation may flag higher pulmonary pressure and hemolytic risk in pediatric sickle cell disease; leaves open prospective outcome validation before screening changes practice.
What is the prevalence of prolonged QTc and its clinical associations in children and young adults with sickle cell disease?
Prolonged QTc is common in children and young adults with sickle cell disease and is associated with elevated pulmonary pressures, hemolysis, and acute chest syndrome, rather than left ventricular hypertrophy.
Liem et al. (2009) studied this question.
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