Key result
In normal canine hearts, dispersion of recovery of excitability was greatest after premature beats, while in ischaemic porcine hearts, refractory periods lengthened centrally and shortened at borders.
This preclinical study demonstrates that while normal hearts are protected from sustained arrhythmias induced by rate changes, ischaemia alters refractory periods and creates conditions for unidirectional block and re-entry.
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No practice change warranted; hypothesis-generating for ischemia-driven re-entry mechanisms needing human validation.
Janse et al. (1985) studied Normal and ischaemic heart electrophysiology. Premature beats and regional ischaemia (LAD clamping) vs. Steady state / normal regions was evaluated on Refractory periods and recovery of excitability. In normal canine hearts, dispersion of recovery of excitability was greatest after premature beats, while in ischaemic porcine hearts, refractory periods lengthened centrally and shortened at borders.
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