Key result
Following coronary occlusion in a canine model, electrophysiological properties deteriorated momentarily, with changes being most severe at the epicardial side of the central ischemic zone.
Why the study?
Does left anterior descending coronary artery occlusion alter electrophysiological properties differently across various zones of the canine myocardium?
Population
Canine heart model of myocardial ischemia
Comparison
Left anterior descending coronary artery occlusion vs Normal zone of the myocardium
Design
Preclinical
Follow-up
10 minutes after occlusion
Authors
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Should not change practice; hypothesis-generating for zone-specific arrhythmia mechanisms in ischemia.
Does left anterior descending coronary artery occlusion alter electrophysiological properties differently across various zones of the canine myocardium?
Acute myocardial ischemia induces rapid, spatially heterogeneous electrophysiological deterioration that is most pronounced in the epicardial central zone.
Okumura et al. (1983) studied Myocardial ischemia. Left anterior descending coronary artery occlusion vs. Normal zone / baseline was evaluated on Time course of changes in excitability threshold, effective refractory period, and local conduction time. Following coronary occlusion in a canine model, electrophysiological properties deteriorated momentarily, with changes being most severe at the epicardial side of the central ischemic zone.
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