Why the study?
How does coronary artery occlusion affect the electrophysiological characteristics of canine Purkinje and myocardial cells in acute and chronic phases?
How does coronary artery occlusion affect the electrophysiological characteristics of canine Purkinje and myocardial cells in acute and chronic phases?
The study demonstrates that while both Purkinje and myocardial cells are acutely injured during myocardial infarction, Purkinje cells can survive and recover normal electrophysiological function in the chronic phase.
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Animal data suggest Purkinje recovery may underlie late post-MI arrhythmias; leaves open human translation.
Lazzara et al. (1974) studied this question.
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