December 1, 1983Clinical Science

Study of the Electrophysiological Effects of Early or Subendocardial Ischaemia with Intracavitary Electrodes in the Dog

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Population

16 experiments in open chested dogs

Comparison

Transient coronary artery occlusion to produce… vs Baseline (pre-occlusion)

Design

Preclinical

Authors

RDRobert M. DonaldsonBoston University PTPeter TaggartUniversity College London FNF. S. NashatKing Saud University

Discussion

Member takes

Implication

May enable earlier ischaemia detection via intracavitary electrodes in animals; leaves open translation to clinical monitoring.

Structured PICO

Population

16 experiments in open chested dogs

Intervention

Transient (1-3 min) coronary artery occlusion to produce regional subendocardial ischaemia; verapamil infusion (0.4 mg/kg) in a subset of 6 experiments

Comparator

Baseline (pre-occlusion)

Outcome

Electrophysiological patterns of regional subendocardial ischaemia (paced endocardial evoked response and simultaneous endocardial monophasic action potential recordings)surrogate

Intracavitary electrodes can detect early electrical changes of regional subendocardial ischaemia, potentially allowing for earlier detection and assessment of therapy.

Cite This Study

Donaldson et al. (1983) studied this question.

synapsesocial.com/papers/6a9754b4824c98cfb78bd30b https://doi.org/10.1042/cs0650579

View Full Paper

Ask AI

Bookmark

Study of the Electrophysiological Effects of Early or Subendocardial Ischaemia with Intracavitary Electrodes in the Dog

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Study of the Electrophysiological Effects of Early or Subendocardial Ischaemia with Intracavitary Electrodes in the Dog

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider