Every 10 mm Hg increase in systolic blood pressure during exercise was associated with a 13% reduction in all-cause mortality (P=0.030) and a 26% reduction in cardiovascular mortality (P=0.004).
Cohort (n=382)
Is an augmented systolic blood pressure response during exercise associated with improved long-term survival in 75-year-old individuals?
An augmented systolic blood pressure response during exercise is associated with improved long-term survival and reduced cardiovascular mortality in 75-year-old individuals.
Effect estimate: HR 0.87
p-value: p=0.030
OBJECTIVE: Studies on the prognostic importance of the systolic blood pressure (SBP) response during exercise report ambiguous results. Most research focuses on younger and middle-aged selected patient groups and rarely includes women. We investigated the prognostic value of SBP response during exercise testing in 75-year-olds. DESIGN: Prospective observational cohort study. SETTING: A community-based random sample of 75-year-old men and women (n = 382). MAIN OUTCOME MEASURES: The prognostic value of SBP change from rest to peak exercise during a symptom-limited cycle test was evaluated for the endpoints all-cause mortality and cardiovascular mortality during long-term follow-up. RESULTS: After a median follow-up of 10.6 years, 140 (37%) of the participants had died, 64 (17%) from cardiovascular causes. The all-cause mortalities for exercise SBP changes of 55 mm Hg were 5.1, 4.2 and 2.6 per 100 person-years, respectively (logrank 9.6; p = 0.008). For every 10 mm Hg increase in SBP during exercise the relative hazard for all-cause mortality was reduced by 13% (p = 0.030) and for cardiovascular mortality by 26% (p = 0.004) after adjustment for sex, smoking, waist circumference, total/HDL cholesterol ratio, prevalent ischaemic heart disease, hypertension, diabetes, cardiovascular medication, pre-exercise SBP, exercise capacity, resting left ventricular ejection fraction and left ventricular mass index. CONCLUSIONS: Our findings suggest that an augmented SBP response during exercise is associated with an improved long-term survival among community-living 75-year-old individuals.
Hedberg et al. (Thu,) conducted a cohort in Community-living older adults (n=382). Systolic blood pressure response during exercise was evaluated on All-cause mortality and cardiovascular mortality (HR 0.87, p=0.030). Every 10 mm Hg increase in systolic blood pressure during exercise was associated with a 13% reduction in all-cause mortality (P=0.030) and a 26% reduction in cardiovascular mortality (P=0.004).
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