Key result
Left ventricular systolic dysfunction (LVEF ≤0.40) was associated with significantly higher all-cause mortality compared to LVEF >0.40 (27.8% vs. 5.6%, P<0.0001; adjusted RR 4.6, 95% CI 1.6-13.2).
Why the study?
Does impaired left ventricular systolic function (LVEF ≤ 0.40) increase mortality and cardiac morbidity in a general middle-aged and elderly population?
Cross-Sectional (n=764)
Does impaired left ventricular systolic function (LVEF ≤ 0.40) increase mortality and cardiac morbidity in a general middle-aged and elderly population?
Effect estimate: RR 4.6 (95% CI 1.6-13.2)
Absolute Event Rate: 27.8% vs 5.6%
p-value: p=<0.0001
Impaired left ventricular systolic function (LVEF ≤ 0.40) is a strong predictor of all-cause mortality and cardiac morbidity in the general population, regardless of the presence of heart failure symptoms.
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LVEF ≤0.40 signals higher mortality in community adults; extends prior HF data to asymptomatic middle-aged/elderly but leaves open need for prospective trials.
Raymond et al. (2004) conducted a cross-sectional in Left ventricular systolic dysfunction and heart failure (n=764). LVEF ≤ 0.40 vs. LVEF > 0.40 was evaluated on All-cause mortality (RR 4.6, 95% CI 1.6-13.2, p=<0.0001). Left ventricular systolic dysfunction (LVEF ≤0.40) was associated with significantly higher all-cause mortality compared to LVEF >0.40 (27.8% vs. 5.6%, P<0.0001; adjusted RR 4.6, 95% CI 1.6-13.2).
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