What question did this study set out to answer?

To review the mechanisms through which epithelial-mesenchymal transition (EMT), circulating tumor cells (CTCs), and cancer stem cells (CSCs) drive drug resistance and cancer relapse.

May 8, 2015OncotargetOpen Access

EMT, CTCs and CSCs in tumor relapse and drug-resistance

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Authors

AMAbhisek MitraAstraZeneca (Japan)LMLopa MishraNorthwell Health SLShulin LiLincoln University College

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Implication

Review uncovers the interplay between EMT-positive circulating tumor cells and cancer stem cells in advanced cancer, suggesting targets to prevent relapse.

Key Points

To review the mechanisms through which epithelial-mesenchymal transition (EMT), circulating tumor cells (CTCs), and cancer stem cells (CSCs) drive drug resistance and cancer relapse.
Narrative synthesis of recent clinical and preclinical studies examining EMT-positive phenotypes in CTCs.
Evaluation of mechanisms controlling extracellular matrix remodeling and the reactivation of dormant relapse-initiating CSCs.
EMT programming enables circulating tumor cells to acquire stem cell-like characteristics, break dormancy in relapse-initiating CSCs, and remodel the extracellular matrix.
Patients exhibiting EMT-positive circulating tumor cells show lack of response to standard chemotherapies and shortened progression-free survival.

Cite This Study

Mitra et al. (2015) studied this question.

synapsesocial.com/papers/6a088ff31e8b9db648de16df https://doi.org/10.18632/oncotarget.4037

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Implication

Review uncovers the interplay between EMT-positive circulating tumor cells and cancer stem cells in advanced cancer, suggesting targets to prevent relapse.

EMT, CTCs and CSCs in tumor relapse and drug-resistance

Discussion

Member takes

Implication

Key Points

Cite This Study

EMT, CTCs and CSCs in tumor relapse and drug-resistance

Discussion

Member takes

Implication

Key Points

Cite This Study

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