Functional Recovery of Subepicardial Myocardial Tissue in Transmural Myocardial Infarction After Successful Reperfusion
Why the study?
Does subepicardial viable myocardium contribute to the recovery of global left ventricular function after successful reperfusion of a transmural anterior MI?
Population
12 patients with single-vessel disease 1 week after successful reperfusion of a first transmural anterior…
Comparison
Assessment with PET and Magnetic resonance tagging vs Age-matched healthy volunteers and temporal…
Design
Cohort
Follow-up
3 months
Authors
Discussion
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Implication
Viable subepicardial myocardium may aid post-reperfusion EF recovery in anterior MI; hypothesis-generating and requires prospective validation.
Key Points
- This research aims to understand how subepicardial myocardial tissue contributes to heart recovery after a myocardial infarction.
- Studied 12 patients with single-vessel disease after reperfusion of anterior myocardial infarction.
- Measured myocardial blood flow and glucose metabolism using PET.
- Quantified fiber strains and ejection fraction using magnetic resonance tagging at 1 week and 3 months post-infarction.
- Subepicardial fiber shortening improved from -5.1% to -9.9% in impaired regions and from -7.1% to -14.9% in intermediately impaired regions.
- Regional ejection fraction in infarcted myocardium improved from 29.6% to 43.5% (P<0.0001).
- Global ejection fraction increased from 44.2% to 49.3% (P<0.0001).
Structured PICO
Does subepicardial viable myocardium contribute to the recovery of global left ventricular function after successful reperfusion of a transmural anterior MI?
P
Population
12 patients with single-vessel disease 1 week after successful reperfusion of a first transmural anterior myocardial infarction (MI), and age-matched healthy volunteers
I
Intervention
Assessment with PET (myocardial blood flow and glucose metabolism) and Magnetic resonance tagging
C
Comparator
Age-matched healthy volunteers and temporal comparison (1 week vs 3 months)
O
Outcome
Subepicardial fiber shortening, regional ejection fraction, and global ejection fractionsurrogate
Functional recovery of viable subepicardial regions contributes to late improvement in regional and global ejection fraction after reperfused transmural MI.
Cite This Study
Bogaert et al. (1999) studied this question.