Why the study?
Does metoprolol influence ADP-induced platelet aggregation in post-MI patients?
Does metoprolol influence ADP-induced platelet aggregation in post-MI patients?
Metoprolol does not appear to affect ADP-induced platelet aggregation in patients recovering from an acute myocardial infarction.
Metoprolol can be used post-MI without platelet aggregation concerns; confirms beta-blocker effects are independent of this pathway.
The effect of metoprolol on platelet aggregation was investigated in a group of postmyocardial infarction (MI) patients. The study was double-blind and included 63 subjects; 30 patients were maintained on metoprolol and 33 received placebo treatment. Adenosine diphosphate (ADP)-induced platelet aggregation was carried out in each subject close to 4 weeks after the acute MI. It was demonstrated that metoprolol as compared to placebo did not influence ADP-induced platelet aggregation in the present clinical setting.
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Vilén et al. (1985) studied this question.
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