Why the study?
Do metoprolol and propranolol affect venous platelet count and ADP-induced platelet aggregation in young healthy male volunteers?
Do metoprolol and propranolol affect venous platelet count and ADP-induced platelet aggregation in young healthy male volunteers?
Short-term administration of metoprolol increases venous platelet count, but neither metoprolol nor propranolol alters ADP-induced platelet aggregation in healthy volunteers.
No support for anti-aggregatory effects; leaves open relevance of count changes to patients with cardiovascular disease.
In previous studies, we have demonstrated that the oral administration of one single dose of metoprolol as well as of propranolol causes a significant increase in the venous platelet concentration. In the present study, we investigated the effect of metoprolol, administered twice daily over a period of 1 week, on the venous platelet count in a group of healthy volunteers. The results showed that the drug significantly raised the venous platelet concentration over the whole study period. Further, the effect of 1 week's metoprolol and propranolol medication on ADP-induced platelet aggregation was investigated in another group of healthy subjects; the results were compared to those obtained during 1 week of placebo medication. It was demonstrated that neither of the two beta-blocking drugs affected ADP-induced platelet aggregability; this was true on the first as well as on the last day of study.
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Vilén et al. (1983) studied this question.
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