Key result
Intravenous adrenaline increased venous platelet-bound radioactivity by 12% over basal value, while prenalterol caused a significant decrease (P<0.05).
Why the study?
Does adrenergic alpha- and beta-1-receptor stimulation affect peripheral platelet count in healthy male volunteers?
Population
8 healthy male volunteers
Comparison
Intravenous infusions of adrenaline before and… vs Basal values (pre-infusion)
Authors
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Acute adrenaline raises circulating platelet radioactivity; leaves open receptor-specific effects on platelet kinetics and clinical relevance.
Does adrenergic alpha- and beta-1-receptor stimulation affect peripheral platelet count in healthy male volunteers?
p-value: p=<0.05
Alpha-receptor stimulation increases peripheral platelet count by depleting the splenic pool, while beta-receptor stimulation has the opposite effect.
Fredén et al. (1978) studied Healthy volunteers (n=8). Adrenaline and prenalterol vs. Basal value was evaluated on Venous platelet-bound radioactivity (PBR) (p=<0.05). Intravenous adrenaline increased venous platelet-bound radioactivity by 12% over basal value, while prenalterol caused a significant decrease (P<0.05).
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