Key result
Adrenaline infusions increased platelet counts and adhesiveness in healthy males, which was blocked by the beta-blocker pronethalol but not by the alpha-blocker phentolamine.
Why the study?
Do adrenaline blockers (Pronethalol or Phentolamine) prevent the rise in platelet counts and adhesiveness produced by adrenaline infusions in young, healthy, male subjects?
Population
Young, healthy, male subjects
Comparison
Adrenaline infusions combined with Pronethalol… vs Adrenaline infusions without blockers
Authors
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Beta-blockade may blunt adrenaline-driven platelet changes in healthy males; leaves open relevance to thrombotic risk or therapy in patients.
Do adrenaline blockers (Pronethalol or Phentolamine) prevent the rise in platelet counts and adhesiveness produced by adrenaline infusions in young, healthy, male subjects?
Beta-blockade with pronethalol, but not alpha-blockade with phentolamine, prevents adrenaline-induced increases in platelet count and adhesiveness in healthy males.
McClure et al. (1965) studied Healthy. Adrenaline infusions with Pronethalol or Phentolamine vs. Adrenaline infusions alone was evaluated on Platelet counts and platelet adhesiveness. Adrenaline infusions increased platelet counts and adhesiveness in healthy males, which was blocked by the beta-blocker pronethalol but not by the alpha-blocker phentolamine.