What question did this study set out to answer?

To evaluate the reactivity of platelets and vascular smooth muscle to low-dose adrenaline infusion in individuals with mild, untreated essential hypertension compared to normotensive controls.

March 1, 1988Journal of Hypertension

Increased platelet and vascular smooth muscle reactivity to low-dose adrenaline infusion in mild essential hypertension

Q: What is the clinical evidence from this study?

Population: Mild essential hypertension (n=35). Intervention: Low-dose adrenaline infusion vs. Normotensive subjects and saline infusion. Primary outcome: Change in platelet count (p=<0.01).

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Key result

Low-dose adrenaline infusion elicited a significantly greater increase in platelet count, enhanced platelet release, and more pronounced forearm vasodilation in hypertensive than normotensive men.

Why the study?

Does low-dose adrenaline infusion elicit different platelet and vascular responses in men with mild essential hypertension compared to normotensive men?

Population

35 men aged 40 years, comprising 12 with mild, untreated hypertension and 23 normotensive controls.

Comparison

Low-dose adrenaline infusion vs Normotensive men receiving equal low-dose…

Follow-up

During infusion

Authors

KLKnut LandeOslo University Hospital SKSverre E. KjeldsenPreventive Cardiology IOIngrid OsOslo University Hospital

Discussion

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Implication

Exaggerated adrenaline responses in mild hypertension may reflect altered sensitivity; hypothesis-generating and should not yet change practice.

Key Points

To evaluate the reactivity of platelets and vascular smooth muscle to low-dose adrenaline infusion in individuals with mild, untreated essential hypertension compared to normotensive controls.
Assessed platelet count, platelet size, plasma beta-thromboglobulin (BTG), and forearm vascular resistance (FVR) before and during low-dose adrenaline infusion.
Included 12 men aged 40 years with mild untreated hypertension, 11 normotensive controls receiving an identical adrenaline infusion, and 12 normotensive controls receiving saline infusion.
In hypertensive men, adrenaline increased platelet count from 195 to 226 × 10^9/l (P < 0.001), platelet size from 7.31 to 7.53 × 10^-15/l (P < 0.01), BTG from 0.61 to 1.08 nmol/l (P < 0.02), and reduced FVR from 97 to 58 units (P < 0.001).
In normotensive men receiving adrenaline, platelet count rose significantly less (from 187 to 201 × 10^9/l, P < 0.01 vs. hypertensive P < 0.01), with no significant changes in platelet size, BTG, or FVR despite similar arterial adrenaline levels (2.5 vs 2.4 nmol/l).
Normotensive controls receiving saline showed no significant changes in any measured platelet parameters or FVR.

Structured PICO

Does low-dose adrenaline infusion elicit different platelet and vascular responses in men with mild essential hypertension compared to normotensive men?

Population

35 40-year-old men, including 12 with mild untreated hypertension and 23 normotensive controls, underwent low-dose adrenaline or saline infusion to assess platelet and vascular reactivity.

Intervention

Low-dose adrenaline infusion

Comparator

Normotensive men receiving equal low-dose adrenaline infusion, and normotensive men receiving saline infusion

Outcome

Changes in platelet count, platelet size, plasma beta-thromboglobulin (BTG), and forearm vascular resistance (FVR)surrogate

Main Result

p-value: p=<0.01

Men with mild essential hypertension exhibit exaggerated platelet reactivity and vascular smooth muscle relaxation in response to low-dose adrenaline compared to normotensive individuals.

Cite This Study

Lande et al. (1988) studied Mild essential hypertension (n=35). Low-dose adrenaline infusion vs. Normotensive subjects and saline infusion was evaluated on Change in platelet count (p=<0.01). Low-dose adrenaline infusion elicited a significantly greater increase in platelet count, enhanced platelet release, and more pronounced forearm vasodilation in hypertensive than normotensive men.

synapsesocial.com/papers/6a92ce179da65ccb784a24ad https://doi.org/10.1097/00004872-198803000-00006

Topics

Hypertension management

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Implication

Exaggerated adrenaline responses in mild hypertension may reflect altered sensitivity; hypothesis-generating and should not yet change practice.

Increased platelet and vascular smooth muscle reactivity to low-dose adrenaline infusion in mild essential hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Topics

Increased platelet and vascular smooth muscle reactivity to low-dose adrenaline infusion in mild essential hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Also Consider

Topics

Also Consider