Key result
Untreated essential hypertension in 50-year-old men was associated with elevated plasma beta-thromboglobulin compared to normotensive controls (p<0.01).
Why the study?
Are plasma beta-thromboglobulin levels elevated in men with untreated essential hypertension compared to normotensive controls, and do they correlate with arterial adrenaline and lipids?
Case-Control (n=37)
Are plasma beta-thromboglobulin levels elevated in men with untreated essential hypertension compared to normotensive controls, and do they correlate with arterial adrenaline and lipids?
Middle-aged men with essential hypertension exhibit increased platelet activity that correlates with arterial adrenaline and cholesterol levels, suggesting interrelated risk factors for coronary artery disease.
Answers are grounded in this paper and cite their sources.
Suggests heightened platelet activation in middle-aged hypertensive men; leaves open its prognostic role and need for prospective validation.
Twenty-three 50-year-old men with untreated, essential hypertension had elevated plasma concentrations of the platelet release product beta-thromboglobulin (BTG) compared to 14 age-matched control men (p less than 0.01). BTG correlated with arterial plasma adrenaline concentrations in the hypertensive (r = 0.44, p less than 0.05), normotensive (r = 0.73, p less than 0.01) and combined group (r = 0.51, p less than 0.01). Significant correlations (p less than 0.05) between BTG and cholesterol (LDL + VLDL fraction) were observed both in the hypertensive and the normotensive group. In the hypertensive group arterial adrenaline correlated with cholesterol (LDL + VLDL) (p less than 0.05). These findings are consistent with increased platelet activity in middle-aged men with essential hypertension, and may indicate that plasma adrenaline influence platelet function. The risk factors for coronary artery disease (blood pressure, lipid status, stress as evidenced by catecholamine release and platelet function) were positively related. Measurement of arterial instead of venous adrenaline is essential for the demonstration of the associations presented.
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Kjeldsen et al. (1983) conducted a case-control in Essential hypertension (n=37). Untreated essential hypertension vs. Normotensive controls was evaluated on Plasma concentrations of beta-thromboglobulin (BTG) (p=<0.01). Untreated essential hypertension in 50-year-old men was associated with elevated plasma beta-thromboglobulin compared to normotensive controls (p<0.01).
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