Key result
Hypertension in men is linked to elevated beta-TG and PF4 levels that rise with stage.
Population
258 men, comprising 116 with essential hypertension and 142 normotensive controls.
Design
Cross-sectional
Authors
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May reflect platelet activation in hypertension; hypothesis-generating for biomarker utility, requiring prospective validation before clinical use.
Observational (n=258)
Plasma levels of beta-thromboglobulin and platelet factor 4 are elevated in essential hypertension and correlate with disease stage, serving as indicators of in vivo platelet activation.
Yamanishi et al. (1985) conducted an observational in Essential Hypertension (n=258). Essential hypertension vs. Normotensive was evaluated on Plasma beta-thromboglobulin (beta TG) and platelet factor 4 (PF4) levels. Plasma beta-thromboglobulin and platelet factor 4 were significantly higher in hypertensive men compared to normotensive men, increasing with the stage of hypertension.
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