Patients with essential hypertension exhibit an atherogenic lipid profile, but platelet aggregation does not appear to correlate with these lipid abnormalities in this population.
Atherogenic lipids in hypertension support screening; cross-sectional data leaves platelet aggregation links open for prospective study.
The relationships among platelet aggregation, lipase activity, age, and body mass index (BMI) were evaluated in 68 patients with essential hypertension. The hypertensives showed an increase in the plasma total cholesterol (TC), total triglycerides (TG), very low density lipoprotein cholesterol (VLDL-C), and low-density lipoprotein cholesterol (LDL-C) levels as compared with the normal subjects. The high-density lipoprotein cholesterol (HDL-C) showed no significant change, but the TC/HDL-C ratio was significantly higher in this group as compared with that of the normal subjects. Partial correlations by adjustment for age, BMI, and interrelated factors in the hypertensive group showed significant, positive correlations between TC and phospholipids (PL), PL and TG, TC and LDL-C and TC and TC/HDL-C ratio and a significant inverse correlation between HDL-C and LDL-C. Platelet aggregation did not correlate significantly with any of the metabolic variables studied in this group.
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Jethmalani et al. (1989) studied this question.
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