Why the study?
Do patients with non-insulin-dependent diabetes mellitus have altered plasma lipids, lipoproteins, and platelet aggregation compared to non-diabetic controls?
Do patients with non-insulin-dependent diabetes mellitus have altered plasma lipids, lipoproteins, and platelet aggregation compared to non-diabetic controls?
Patients with non-insulin-dependent diabetes mellitus exhibit an atherogenic lipid profile and increased platelet aggregability, predisposing them to a higher risk of coronary heart disease.
May signal elevated CHD risk via lipids and platelets in diabetes; leaves open causal role pending prospective confirmation.
We compared plasma lipids, lipoproteins, platelet aggregation, plasma lipase activity, age, and body mass index (BMI) between patients with non-insulin-dependent diabetes mellitus and non-diabetic controls. Diabetic subjects showed significantly higher levels of plasma total triglycerides (TG) and very-low-density lipoprotein cholesterol (VLDL-C) and significantly increased platelet aggregability. The total cholesterol (TC)/high-density lipoprotein cholesterol (HDL-C) ratio was also significantly higher consequent to the significantly lower HDL-C levels in the diabetic subjects when compared with non-diabetic controls. The diabetic group showed positive significant correlations between TC and low-density lipoprotein cholesterol (LDL-C), HDL-C and plasma lipase activity, and TG and TC/HDL-C ratio, whereas significant inverse correlations were observed between TG and HDL-C, HDL-C and TC/HDL-C ratio. Platelet aggregation did not correlate significantly with any of the metabolic variables studied in this group.
No takes yet. Share an insight, caveat, or question.
Jethmalani et al. (1989) studied this question.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: