Why the study?
At diagnosis, the lipid profile of Type 2 diabetic patients and its relation to insulin action and adipose distribution was not fully characterized.
Population
545 subjects screened for diabetes mellitus
Comparison
Diabetic patients vs subjects with normal glucose tolerance
Design
Cross-sectional study
Follow-up
17.5 +/- 4.6 months in a subset of 13 diabetic patients
Key result
Type 2 diabetes at diagnosis was associated with an atherogenic lipid profile, including significantly higher triglycerides and lower HDL-cholesterol compared to normal glucose tolerance (p<0.05).
Authors
Loading...
Prompts lipid screening at T2D diagnosis; leaves open whether adiposity or insulin primarily mediates the profile.
Cross-Sectional (n=545)
p-value: p=<0.05
At diagnosis, Type 2 diabetic patients exhibit an atherogenic lipid profile characterized by high triglycerides and low HDL-cholesterol, which may be related to adipose distribution and insulin action.
Sosenko et al. (1993) conducted a cross-sectional in Type 2 Diabetes Mellitus (n=545). Type 2 diabetes mellitus vs. Normal glucose tolerance was evaluated on Triglyceride and HDL-cholesterol levels (p=<0.05). Type 2 diabetes at diagnosis was associated with an atherogenic lipid profile, including significantly higher triglycerides and lower HDL-cholesterol compared to normal glucose tolerance (p<0.05).