What question did this study set out to answer?

To determine serum cholesterol and triglyceride levels across major lipoprotein fractions in chronic insulin-treated diabetic patients compared to nondiabetic controls.

November 1, 1978Diabetes

Serum Lipids and Lipoproteins in Insulin-treated Diabetes: Demonstration of Increased High Density Lipoprotein Concentrations

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Why the study?

Does insulin-treated diabetes alter serum lipid and lipoprotein concentrations compared to nondiabetic controls?

Population

170 nonuremic middle-aged diabetic patients who had been treated with insulin for a minimum of 10 years

Comparison

Insulin-treated diabetes vs Nondiabetic control subjects of the same age and…

Design

Case-control

Authors

ENEsko A. NikkiläGeneral / Preventive / Lipids PHP. HormilaJorvi Hospital

Discussion

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Implication

Higher HDL in insulin-treated diabetes should not revise risk estimates; leaves open non-lipid drivers of excess cardiovascular events.

Key Points

To determine serum cholesterol and triglyceride levels across major lipoprotein fractions in chronic insulin-treated diabetic patients compared to nondiabetic controls.
Assessed serum lipid and lipoprotein fractions in N=170 nonuremic, middle-aged diabetic patients treated with insulin for at least 10 years and matched nondiabetic controls.
Measured postheparin plasma lipoprotein lipase activity in a subsample of diabetic participants and controls.
Total serum cholesterol and triglyceride levels did not differ from controls, but HDL-cholesterol was significantly higher in male and female diabetic patients than in controls (P < 0.001).
Male diabetic patients with poor glycemic control or overweight exhibited elevated triglycerides and VLDL-triglycerides, whereas overweight patients had elevated total cholesterol and LDL-cholesterol.
Postheparin plasma lipoprotein lipase activity was higher in diabetic patients than in controls and correlated positively with HDL-cholesterol levels, regardless of body weight or glycemic control.

Structured PICO

Does insulin-treated diabetes alter serum lipid and lipoprotein concentrations compared to nondiabetic controls?

Population

170 nonuremic middle-aged diabetic patients who had been treated with insulin for a minimum of 10 years

Intervention

Insulin-treated diabetes (minimum 10 years duration)

Comparator

Nondiabetic control subjects of the same age and sex

Outcome

Cholesterol and triglyceride concentrations in serum and in three major lipoprotein fractions (including HDL-cholesterol)surrogate

Insulin-treated chronic diabetic patients have increased HDL-cholesterol and a non-atherogenic lipid profile compared to controls, suggesting that their excess cardiovascular risk is driven by other factors.

Cite This Study

Nikkilä et al. (1978) studied this question.

synapsesocial.com/papers/6a770f76d8eb58afc2bd980b https://doi.org/10.2337/diab.27.11.1078

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Serum Lipids and Lipoproteins in Insulin-treated Diabetes: Demonstration of Increased High Density Lipoprotein Concentrations

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Serum Lipids and Lipoproteins in Insulin-treated Diabetes: Demonstration of Increased High Density Lipoprotein Concentrations

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider