Insulin therapy induces antiatherogenic changes of serum lipoproteins in noninsulin-dependent diabetes.
Key result
Four weeks of insulin therapy significantly decreased VLDL triglycerides (-60%, p<0.001) and increased HDL2 mass (127 to 158 mg/dl, p<0.001) in patients with noninsulin-dependent diabetes.
Why the study?
Does rigorous insulin therapy improve serum lipoproteins in patients with noninsulin-dependent diabetes not controlled with oral agents?
Population
19 patients with noninsulin-dependent diabetes not controlled with oral agents only, mean age 58 +/- 1 years.
Comparison
Rigorous insulin therapy for 4 weeks. vs Baseline (before insulin therapy).
Design
Cohort
Follow-up
4 weeks
Authors
Discussion
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Member takes
Implication
Supports antiatherogenic lipoprotein shifts with insulin in NIDDM; leaves open effects on clinical events.
Structured PICO
Does rigorous insulin therapy improve serum lipoproteins in patients with noninsulin-dependent diabetes not controlled with oral agents?
P
Population
19 adults (mean age 58) with noninsulin-dependent diabetes poorly controlled on oral agents, evaluated before and after 4 weeks of intensive insulin therapy.
I
Intervention
Rigorous insulin therapy for 4 weeks.
C
Comparator
Baseline (before insulin therapy).
O
Outcome
Changes in serum lipoproteins, apoproteins, lipolytic enzymes, and glucose disposal.surrogate
Main Result
Absolute Event Rate: 158% vs 127%
p-value: p=<0.001
Intensive insulin therapy in noninsulin-dependent diabetes induces antiatherogenic changes in serum lipoproteins, likely driven by increased lipoprotein lipase activity.
Cite This Study
Taskinen et al. (1988) studied Noninsulin-dependent diabetes (n=19). Insulin therapy vs. Baseline (before insulin therapy) was evaluated on HDL2 mass (mg/dl) (p=<0.001). Four weeks of insulin therapy significantly decreased VLDL triglycerides (-60%, p<0.001) and increased HDL2 mass (127 to 158 mg/dl, p<0.001) in patients with noninsulin-dependent diabetes.