What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Glucose abnormalities (Type 2 Diabetes, Pre-Diabetes, Normal Glucose Tolerance) (n=1091). Intervention: Female sex vs. Male sex. Primary outcome: Differences in lipid profiles (triglycerides, HDL-C, LDL-C, apolipoproteins) (p=<0.05).

What does this research mean for the field?

Progression of glucose intolerance to type 2 diabetes is associated with a disproportionate worsening of plasma lipid profiles in women relative to men, reducing their baseline cardiovascular risk advantage. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

September 28, 2011Journal of Diabetes

Sex differences in lipid profiles in relation to the progression of glucose abnormalities

Q: What are the key findings of this study?

Progression of glucose intolerance from normal to type 2 diabetes involves a worsening of plasma lipid composition in women compared to men, reducing their cardiovascular protection.

Q: What does this research mean for the field?

Progression of glucose intolerance to type 2 diabetes is associated with a disproportionate worsening of plasma lipid profiles in women relative to men, reducing their baseline cardiovascular risk advantage. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

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Key result

Progression to type 2 diabetes linked to worse lipid profile changes in women than men.

P<0.05
n=1,091

Why the study?

The study investigated the role of changes in blood lipids in the loss of the lower cardiovascular risk associated with female gender in individuals with type 2 diabetes mellitus.

Population

1091 consecutive patients undergoing OGTT including 478 men and 613 women

Comparison

Lipid profiles across glucose tolerance groups and between sexes

Design

Cross-sectional study

Authors

GSGian Piero Carnevale SchiancaUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro”GFGian Paolo FraUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro”ECE. Colli

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Implication

Study Design

Type

Cross-Sectional (n=1,091)

PICO

Population

1,091 consecutive patients undergoing oral glucose tolerance testing to evaluate sex differences in lipid profiles across normal glucose tolerance, pre-diabetes, and type 2 diabetes.

Exposure / Comparator

Female sex vs Male sex

Primary Outcome

Differences in lipid profiles (triglycerides, HDL-C, LDL-C, apolipoproteins), p=<0.05

Main Result

p-value: p=<0.05

Cite This Study

Schianca et al. (2011) conducted a cross-sectional in Glucose abnormalities (Type 2 Diabetes, Pre-Diabetes, Normal Glucose Tolerance) (n=1,091). Female sex vs. Male sex was evaluated on Differences in lipid profiles (triglycerides, HDL-C, LDL-C, apolipoproteins) (p=<0.05). Progression of glucose intolerance from normal to type 2 diabetes involves a worsening of plasma lipid composition in women compared to men, reducing their cardiovascular protection.

synapsesocial.com/papers/6ac5fe3bbae1837e50d38596 https://doi.org/10.1111/j.1753-0407.2011.00160.x

Topics

Women and heart disease

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Sex differences in lipid profiles in relation to the progression of glucose abnormalities

Discussion

Member takes

Implication

Study Design

PICO

Main Result

Cite This Study

Topics

Sex differences in lipid profiles in relation to the progression of glucose abnormalities

Discussion

Member takes

Implication

Study Design

PICO

Main Result

Cite This Study

Also Consider

Topics

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