What question did this study set out to answer?

To evaluate the statics and dynamics of colloidal particles adhering to cell membranes when competing for mobile surface receptors as a function of bulk concentration.

November 1, 2003EPL (Europhysics Letters)

Adhesion of colloids on a cell surface in competition for mobile receptors

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Authors

DED. van EffenterreCentre National de la Recherche Scientifique DRD. RouxCentre National de la Recherche Scientifique

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Implication

Theoretical modeling demonstrates two distinct adhesion regimes for colloids on cell membranes, suggesting that bulk concentration directly regulates surface residence time.

Key Points

To evaluate the statics and dynamics of colloidal particles adhering to cell membranes when competing for mobile surface receptors as a function of bulk concentration.
Formulated a thermodynamic model describing Brownian colloidal particles bearing specific surface ligands interacting with freely diffusing membrane receptors.
Calculated particle adsorption density and the mean number of receptor-ligand bonds per colloid across varying bulk volume fractions.
Identified a low-concentration regime where the density of adherent colloids scales linearly with volume fraction while maintaining a constant number of receptor bonds per particle.
Identified a high-concentration regime where receptor competition reduces the number of bonds per colloid, directly modifying particle residence time on the cell surface.

Cite This Study

Effenterre et al. (2003) studied this question.

synapsesocial.com/papers/6a089947ab15ea61dee8f4fa https://doi.org/10.1209/epl/i2003-00268-x

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Implication

Theoretical modeling demonstrates two distinct adhesion regimes for colloids on cell membranes, suggesting that bulk concentration directly regulates surface residence time.

Adhesion of colloids on a cell surface in competition for mobile receptors

Discussion

Member takes

Implication

Key Points

Cite This Study

Adhesion of colloids on a cell surface in competition for mobile receptors

Discussion

Member takes

Implication

Key Points

Cite This Study

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