Key result
Plasma fibulin-1 levels were significantly higher in patients with aortic valve stenosis or atrial fibrillation compared to those with coronary artery disease only (p=0.005).
Why the study?
Do patients with aortic valve stenosis or atrial fibrillation have higher plasma fibulin-1 levels compared to those with coronary artery disease only?
Observational (n=293)
No
Do patients with aortic valve stenosis or atrial fibrillation have higher plasma fibulin-1 levels compared to those with coronary artery disease only?
p-value: p=0.005
Plasma fibulin-1 levels are elevated in patients with aortic stenosis or atrial fibrillation compared to those with coronary artery disease alone, suggesting its potential role as a marker of extracellular matrix turnover.
OBJECTIVES: Aortic valve stenosis (AS) causes cardiac fibrosis and left ventricular hypertrophy, and over time heart failure can occur. To date, a reliable marker to predict progression of AS or the development of heart failure is still lacking. In this study, we addressed the hypothesis that fibulin-1 levels reflect myocardial fibrosis. METHODS: Patients undergoing heart surgery at the Odense University were investigated. By 2012 data on outcome were obtained. RESULTS: In 293 patients, plasma fibulin-1 levels were measured. Patients with AS or atrial fibrillation (AF) had significantly higher fibulin-1 levels compared to those with coronary artery disease only (p = 0.005). Patients with preoperatively diagnosed chronic AF had significantly higher levels of fibulin-1 compared to those without (p = 0.004). Plasma fibulin-1 levels showed no relationship to echocardiographic size and had no impact on outcome, death or other adverse events. CONCLUSION: This study shows that plasma fibulin-1 levels are increased in patients with AS and AF compared to patients with coronary disease only. Our study results suggest fibulin-1, a vascular extracellular matrix (ECM) protein, as a marker of ECM turnover perhaps due to the increased myocardial stretch that is related to pressure overload.
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Hansen et al. (2013) conducted an observational in Aortic valve stenosis and atrial fibrillation (n=293). Plasma fibulin-1 levels (biomarker) vs. Patients with coronary artery disease only was evaluated on Plasma fibulin-1 levels (p=0.005). Plasma fibulin-1 levels were significantly higher in patients with aortic valve stenosis or atrial fibrillation compared to those with coronary artery disease only (p=0.005).
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