Key result
Verapamil and magnesium sulfate reduced ventricular fibrillation during ischemia (9.1-25% across treated groups vs 50% in controls) and following reperfusion in a canine model.
Why the study?
Does verapamil or magnesium sulfate reduce electrophysiologic changes and ventricular fibrillation during acute myocardial ischemia and reperfusion in dogs?
Does verapamil or magnesium sulfate reduce electrophysiologic changes and ventricular fibrillation during acute myocardial ischemia and reperfusion in dogs?
In a canine model, verapamil and magnesium sulfate administered via coronary sinus retroperfusion were highly effective at preventing ischemia- and reperfusion-induced electrophysiologic changes and ventricular arrhythmias.
No takes yet. Share an insight, caveat, or question.
Hypothesis-generating in canine ischemia-reperfusion; should not change clinical practice pending human trials.
Yamamoto et al. (1996) studied Acute myocardial ischemia and reperfusion (n=65). Verapamil and magnesium sulfate (intravenous or coronary sinus retroperfusion) vs. Control was evaluated on Ventricular fibrillation during ischemia. Verapamil and magnesium sulfate reduced ventricular fibrillation during ischemia (9.1-25% across treated groups vs 50% in controls) and following reperfusion in a canine model.
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