Key result
Urgent TEER linked to ~181% higher in-hospital mortality versus elective procedures.
Why the study?
Urgent cardiac interventions carry poor outcomes, but predictors of urgent versus elective TMVr and the association between urgency and outcomes remained uncharacterized at a national level.
Does urgent TMVr compared to elective TMVr result in worse in-hospital outcomes, and what are the predictors of urgent TMVr?
Observational (n=10,195)
Yes
Does urgent TMVr compared to elective TMVr result in worse in-hospital outcomes, and what are the predictors of urgent TMVr?
Absolute Event Rate: 4.5% vs 1.6%
p-value: p=< .001
Urgent TMVr is associated with significantly higher in-hospital mortality, length of stay, and costs compared to elective TMVr, with racial and socioeconomic disparities driving urgent admissions.
Urgent TMVr warrants caution in referrals; observational data leaves open selection bias versus causal timing effects.
BACKGROUND: Cardiac interventions performed urgently are known to be associated with poor outcomes compared with electively performed procedures. Transcatheter edge-to-edge mitral valve repair (TMVr) has developed as a reasonable alternative to mitral valve surgery in certain patient populations. We aimed to leverage a national database to identify predictors of urgent versus elective TMVr, as well as the association between urgency and outcomes. METHODS: The National Inpatient Sample (NIS) was queried to identify patients who underwent TMVr from 2016 to 2017. Hospitalizations were identified within the database as elective versus nonelective. Univariate and multivariable analyses were performed to identify patient characteristics associated with urgent procedures. In-hospital outcomes were assessed. RESULTS: There were 10,195 cases of TMVr in this cohort, 24.2% of which were performed urgently. In multivariable analysis, Hispanic race, Medicaid insurance, and low income were associated with increased likelihood of urgent hospital admission and TMVr. Additionally, small hospital size and Northeast region were associated with increased likelihood of urgent admission and procedure. Urgent TMVr was associated with increased mortality (4.5% vs. 1.6%, p < .001), prolonged length of stay (6.0 vs. 2.0, p < .001), and increased cost ($71,451.90 vs. $44,981.20, p < .001). CONCLUSIONS: Racial and socioeconomic disparities exist in the utilization of TMVr as an urgent versus elective procedure, suggesting differences in access to surveillance and preventive care. Urgent TMVr is associated with increased morbidity and mortality, prolonged length of stay, and increased hospital costs. Priority should be placed on mitigating such disparities to improve outcomes.
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Spring et al. (2021) conducted an observational in Mitral valve disease requiring TMVr (n=10,195). Urgent TMVr vs. Elective TMVr was evaluated on In-hospital mortality (p=< .001). Urgent transcatheter edge-to-edge mitral valve repair was associated with significantly increased in-hospital mortality compared to elective procedures (4.5% vs. 1.6%, p < .001).
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