November 1, 1983Circulation ResearchOpen Access

Cardiac and pulmonary norepinephrine release and removal in the dog.

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Population

Anesthetized dogs

Comparison

Sympathetic stimulation and epicardial pacing vs Resting conditions

Design

Preclinical

Authors

PBPeter BlomberyBrigham and Women's Hospital BHBirger HeinzowLandesamt für Landwirtschaft, Umwelt und ländliche Räume

Discussion

Member takes

Implication

Caution against direct extrapolation to patients; extends basic science understanding of norepinephrine spillover.

Structured PICO

Population

Anesthetized dogs

Intervention

Sympathetic stimulation and epicardial pacing

Comparator

Resting conditions

Outcome

Norepinephrine extraction and spillover rates in the heart and lungssurrogate

The study demonstrates that norepinephrine extraction and spillover can be separated in the dog heart and lungs, with spillover increasing significantly during sympathetic stimulation but not pacing.

Cite This Study

Blombery et al. (1983) studied this question.

synapsesocial.com/papers/6a08caee96b78901e666c207 https://doi.org/10.1161/01.res.53.5.688

View Full Paper

Ask AI

Bookmark

Cardiac and pulmonary norepinephrine release and removal in the dog.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cardiac and pulmonary norepinephrine release and removal in the dog.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider