Population
Humans (assessing regional sympathetic function in the heart, kidneys, and forearm)
Design
Other
Authors
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Plasma norepinephrine spillover markedly underestimates organ-specific sympathetic activity; leaves open accurate regional assessment without tissue uptake corrections.
Norepinephrine release greatly and variably exceeds its spillover into plasma across different organs, highlighting the need to account for tissue uptake when assessing regional sympathetic function.
Kopin et al. (1998) studied this question.
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