March 1, 1989American Journal of Hypertension
Noradrenaline Release and the Pathophysiology of Primary Human Hypertension
Key result
Mean total norepinephrine spillover in hypertensive patients was 42% higher than in normal subjects, primarily due to increased renal and cardiac spillover.
Population
Patients with primary human hypertension and healthy subjects with normal blood pressure
Design
Case-control
Authors
Discussion
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Implication
Selective sympathetic activation may contribute to early hypertension; hypothesis-generating and should not yet change practice.
Structured PICO
P
Population
Patients with primary human hypertension and healthy subjects with normal blood pressure
C
Comparator
Subjects with normal blood pressure
O
Outcome
Total and regional norepinephrine spillover to plasmasurrogate
Sympathetic nervous outflow to the kidneys and heart is selectively activated in early primary hypertension, particularly in patients under 40 years of age.
Cite This Study
Esler et al. (1989) studied this question. Mean total norepinephrine spillover in hypertensive patients was 42% higher than in normal subjects, primarily due to increased renal and cardiac spillover.