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April 1, 1991HypertensionOpen Access

Higher rates of norepinephrine spillover into the cerebrovascular circulation were found in patients with essential hypertension compared to healthy subjects.

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Population

Patients with primary human hypertension (essential hypertension) and healthy subjects

Comparison

Radiotracer measurement of norepinephrine… vs Healthy subjects

Design

Review

Authors

MEMurray EslerCFClaudia FerrierGLGavin Lambert

Discussion

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Overview

May implicate central sympathetic overdrive in essential hypertension; leaves open whether targeting CNS norepinephrine improves outcomes.

Structured PICO

P
Population
Patients with primary human hypertension (essential hypertension) and healthy subjects
I
Intervention
Radiotracer measurement of norepinephrine overflow to plasma
C
Comparator
Healthy subjects
O
Outcome
Norepinephrine spillover to plasma and cerebrovascular circulationsurrogate

The study provides biochemical evidence that increased central nervous system norepinephrine turnover may drive sympathetic hyperactivity in essential hypertension.

Cite This Study

Esler et al. (1991) studied this question.

synapsesocial.com/papers/6a7daca0f980e83641187434https://doi.org/10.1161/01.hyp.17.4_suppl.iii29
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